慢性乙型肝炎中医证型与相关性实验指标关系

Clinical study of the relationship between TCM Syndrome and laboratory index of chronic hepatitis B

目的探讨慢性乙型肝炎中医证型与实验室指标的相互关系。方法将慢性乙肝患者按中医辨证分型为湿热中阻、肝郁脾虚、肝肾阴虚、气滞血瘀和脾肾阳虚五个证型各40例,分别做放免两对半定量、HBV-DNA定量、肝功能(ALT、AST、GGT、TBIL、A、G)、肝纤维四项(HA、PC-Ⅲ、LN、IV-C)检测,观察各证型与实验室指标的相互关系。结果湿热中阻型,其HBV-DNA定量、肝功能、HBsAg、HBeAg指标均高于其他各型,由高至低依次为肝郁脾虚型、气滞血瘀型、肝肾阴虚型、脾肾阳虚型,差异有统计学意义(P<0.05)。结论慢性乙型肝炎中医证型各型之间肝纤维四项、HBV-DNA、HBsAg、HBeAg、ALT、AST、GGT、TBIL、ALB、GLB有明显差异性。

Objective To discuss the relationship between laboratory index and TCM syndrome of Chronic hepatitis B.Methods The chronic hepatitis B patients according to syndrome differentiation for the stagnation of damp-heat in middle-jiao,stagnation of liver-QI with deficiency of the spleen,liver-kidney Yin deficiency,Qi depression to blood stasis and spleen-kidney Yang deficiency in five types 40 cases each.HbsAg,HbsAb,HbeAg,HbeAb,HbcAb,HBV-DNA quantitative,liver function（ALT,AST,GGT,TBIL,ALB,GLB） and liver fiber（HA,PC III,LN,IV-C）were detected.Observe the TCM syndrome and laboratory index correlation.Results The stagnation of damp-heat in middle-jiao type,the virus number,liver function,HbsAg,HbeAg indicators were higher than those of other type,from high to low is for the stagnation of liver-QI with deficiency of the spleen type,Qi depression to blood stasis type,liver-kidney Yin deficiency type,spleen-kidney Yang deficiency type,the difference is significant（P 0.05）.Conclusion TCM Syndrome of chronic hepatitis B between various types of liver fiber four,HBV-DNA,HBsAg,HBeAg,ALT,AST,GGT,TBIL,ALB,GLB have obvious difference.