门冬胰岛素30与甘精胰岛素注射治疗初诊2型糖尿病临床观察

Clinical observation of insulin aspart 30 and insulin glargine injection in the treatment of newly diagnosed type 2 diabetes

目的观察每天注射一次门冬胰岛素30联合口服药对初诊2型糖尿病患者血糖控制及其对胰岛β细胞功能的影响。方法将64例2型糖尿病患者分为门冬胰岛素30治疗组和甘精胰岛素治疗组，门冬胰岛素30组每日晚餐前注射一次，联合三餐后服二甲双胍或阿卡波糖；甘精胰岛素组睡前注射一次，联合三餐后服二甲双胍或阿卡波糖，观察治疗时间为12周。检测两组治疗前后空腹及餐后血糖、糖化血红蛋白（HbAlc）、C肽等指标，比较两组患者血糖控制情况及胰岛β细胞功能恢复情况。结果门冬胰岛素30治疗组和甘精胰岛素治疗组在降糖，改善胰岛β细胞功能等方面比较差异无统计学意义，但甘精胰岛素组低血糖发生率低于门冬胰岛素30组（P〈0．01）。结论门冬胰岛素30和甘精胰岛素都具有明显的降低空腹和餐后血糖以及HbAlc的作用，用门冬胰岛素30方法联合二甲双胍或阿卡波糖治疗初诊2型糖尿病患者可以达到甘精胰岛素方法同样的效果。

Objective To investigate the therapeutic effect of combination of insulin aspart 30 injection and oral drugs for controling blood glucose and founction of islet 13-cells in type 2 diabetic patients. Methods Sixty-four patients with type 2 diabetic were divided into two groups. Group insulin aspart 30 were injected with insulin aspart 30 once before supper, plus metformin or acarbose postprandial; Group insulin glargine were injected with insulin glargine once before asleep, plus metformin or aearbose postprandial. All patients were treated for 12 weeks. The values of FBS, PBS, HbAlc, C-peptide were periodically measured and compared. Results Both groups apparently decreased the glucose and improved the function of islet B-cells, there was no significant differences. But incidence of hypoglycemia in insulin glargine group was lower than that in insulin aspart 30 group （ P 〈 0. 01 ）. Conclusions Insulinglargine injection in treating type 2 diabetic patients.