2-(2-芳基)乙基苯甲酸的合成

Synthesis of 2-(2-Aryl)ethylbenzoic Acid

以邻氰基氯苄为原料,与苯甲醛或2-噻吩甲醛经Wittig-Horner反应、水解及氢化反应制得2-(2-苯乙基)苯甲酸或2-(2-噻吩基)乙基苯甲酸,总收率分别约64%和60%。

2- （2-Phenylethyl） benzoic acid or 2- （thiophen-2-ylethyl） benzoic acid was synthesized from o-cyanobenzyl chloride via Wittig-Horner reaction with benzaldehyde or 2-thiophene carboxaldehyde, hydrolysis and then hydrogenation with the overall yield of about 64 % or 60 %.