在体单向灌流法研究加巴喷丁的大鼠肠吸收

Intestinal Absorption of Gabapentin in Rats by in situ Single Pass Perfusion

采用在体单向灌流法考察加巴喷丁的大鼠肠吸收特性。结果表明,加巴喷丁在小肠各段(十二指肠段、空肠段和回肠段)和结肠均有吸收。低、中浓度(1和10 mmol/L)时药物在小肠各段的吸收速率常数(Ka)和有效渗透系数(Peff)显著大于结肠段(P<0.05),高浓度(50 mmol/L)时十二指肠段的吸收显著大于结肠段(P<0.05)。加巴喷丁浓度对其在小肠各段的吸收有显著影响,低浓度组小肠各段药物的Ka和Peff显著大于高浓度组(P<0.05),而药物浓度对结肠段的吸收无显著影响。

The intestinal absorption of gabapentin in rats was investigated by means of in situ single pass perfusion. The results showed that gabapentin could be absorbed in the whole small intestine （duodenum, jejunum and ileum） and c^lon. The drug absorption constant （Ka） and effective absorption coefficient （Pe~） of small intestine were higher than those of colon in low and middle concentration （1 and 10 mmol/L） groups （P〈0.05）. The drug absorption in duodenum was significantly higher than colon in high concentration （50 retool/L） group （P〈0.05）. The gabapentin concentration had a significant effect on absorption in small intestine. The Ka and Pofr of small intestine in low concentration group were significantly higher than those of high concentration group （P〈0.05）. However, drug concentration had no effect on absorption in colon.