摘要
建立了高效液相色谱法测定达沙替尼含量及有关物质。采用C18色谱柱,以0.01 mol/L磷酸二氢钾溶液(以氢氧化钠溶液调至pH 5)-乙腈为流动相,梯度洗脱,检测波长230 nm。达沙替尼在5～50μg/ml范围内线性关系良好,最低检测限为0.01μg/ml。
An HPLC method was established for the determination of dasatinib and its related substances. A C18 column was used with the mobile phase of acetonitrile-0.01 mol/L potassium dihydrogen phosphate solution （adjusted to pH 5 with sodium hydroxide solution） by gradient elution, at the detection wavelength of 230 nm. The calibration curve of dasatinib was linear in the concentration range of 5 - 50 μg/ml, with the low limit of detection of 0.01 μg/ml.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2012年第2期129-131,共3页
Chinese Journal of Pharmaceuticals
