腹腔注射复方银杏叶液对小鼠的镇痛作用

The Analgesic Actions of Compound Ginkgo Solution in Rats

目的 :研究复方银杏叶液 (CGS)的镇痛作用。方法 :在小鼠扭体和热板反应模型上观察其用药后扭体数和舔足潜伏期的变化 ,在小鼠温浴法模型上观察甩尾潜伏期的变化 ,并在小鼠耳片肿胀模型上观察小鼠耳片肿胀度。结果 :复方银杏叶液 (CGS) 2 5、5 0、10 0 mg· kg- lip分别显著减少小鼠扭体数 ,显著延长小鼠舔足潜伏期及小鼠温水浴甩尾潜伏期 ,并呈一定的剂量依赖性关系 ,复方银杏叶液 (CGS) 2 5、5 0、10 0 m g·kg- 1 ip显著抑制二甲苯诱导耳片水肿形成。结论 :复方银杏叶液 (CGS)

OBJECTIVE:To study the analgesic action of compound Ginkgo solution (CGS).METHODS:There are were observed the changes latent period of licking paws and writhing numbers with the hot-plate and writhing test in mice,and after administration also were observed on the edema formation test and the changes of the edema degree of ear in mice.RESULTS:CGS(25、50、100mg·kg -1 ip) significantly reduced the writhing numbers dose-dependently and prolonged the latent period of licking paws in mice,CNS(25、50、100 mg·kg -1 ip)significantly inhibited the edema formation of ear induced by dimethybenzen.CONCLUSION:CGS has a significant analgesic action.