112例中药制剂不良反应报告分析

A retrospective analysis of 112 cases of adverse drug reaction of Chinese drug preparations

目的分析中药不良反应（adverse drug reaction，ADR）发生的特点，为临床合理用药提供参考。方法收集2009年～2011年通过网络系统向广州市药品不良反应监测中心上报的112例中药ADR报告，按患者基本情况、给药途径、ADR累及的器官或系统及临床表现、ADR发生时间等进行统计分析。结果112例ADR共涉及26个品种，中老年患者ADR的发生率最高（42．68％）；注射给药是引发ADR的主要给药途径（占93．75％）；皮肤及其附件损害最常见（50．97％）；用药当天发生ADR的比例最大（54．47％）。结论药品不良反应报告的内容和统计资料是加强药品监督管理、指导合理用药的依据。

Objective To study the characteristics and regularities of Chinese drugs preparations ADR in order to improve the rational drug use. Methods A total of 112 cases of TCM ADR reports collected in 2009-2011 which have been presented to the Guangzhou ADR Monitoring Center. Results Of the 112 cases, 26 kinds of drugs were involved, quinquagenarian were the main crowd, intravenous infusion was the main route of administration, the main types of TCM ADR were lesions of skin and accessories. Conclusion Great importance should be attached to TCM ADR monitoring to promote rational drug use in the clinic.