新型离子液体催化合成喹唑啉酮衍生物的研究

Novel ionic liquids catalyzed synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones

目的制备新型离子液体催化剂,用于改进喹唑啉酮衍生物的合成工艺。方法以低成本开发新型离子液体,用于催化邻氨基苯甲酰胺与系列芳香醛缩合制备2-芳基-2,3-二氢喹唑啉-4(1H)-酮化合物。结果用一锅法合成了苯并噻唑六氟磷酸盐离子液体;使用该离子液体催化制备2-芳基-2,3-二氢喹唑啉-4(1H)-酮化合物的收率为77%～91%,产物易于分离且离子液体可循环使用5次以上。结论所开发的离子液体制备成本低、过程环保;以该离子液体为催化剂建立的2-芳基-2,3-二氢喹唑啉-4(1H)-酮化合物的合成方法简便易行。

OBJECTIVE To improve the synthesis method of 2-aryl-2,3-dihydroquinazolin-4（1H）-ones by using novel ionic liquids.METHODS Novel ionic liquids with low costs was prepared.The reaction of anthranilamide and aromatic aldehydes for the synthesis of 2-aryl-2,3-dihydroquinazolin-4（1H）-ones was catalyzed.RESULTS Ionic liquid was synthesized at low costs by using one-pot method.2-Aryl-2,3-dihydroquinazolin-4（1H）-ones were obtained with 77%-91% yields,ionic liquid was easy to be separated from the products and could be reused at least five times.CONCLUSION Benzothiazolium hexafluorophosphate ionic liquids catalyzed synthesis of 2-aryl-2,3-dihydroquinazolin-4（1H）-ones is an environmentally friendly method,which could also simplify the procedure and reduce the costs.