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伪膜性肠炎发病机制及诊疗的探讨 被引量:4

Study on diagnosis and treatment of pseudomembranous enterocolitis
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摘要 [目的]探讨伪膜性肠炎的发病机制。[方法]结合病史,对1例复发性伪膜性肠炎患者的临床症状、体征,实验室检查和肠镜及其组织病理学进行分析。[结果]以反复腹痛、腹泻为主要临床症状的伪膜性肠炎患者,多次大便培养示肠道菌群失调。[结论]抗生素致肠道菌群失调是引起伪膜性肠炎的主要原因,合理使用抗生素和恢复肠道菌群是伪膜性肠炎的主要治疗手段。 [Objective]To study the pathogenesis of pseudomembranous enterocolitis. [Meth- ods]Based on the medical record, clinical symptoms, signs, laboratory examination, histopathology and endoscopic images were analyzed in a colon patient who was diagnosed as recurrent pseudomembranous enterocolitis. [Results] Alteration of intestinal flora always existed in the pseudomembranous enterocolitis patient who suffered from repeated abdominal pain and diarrhea. [Conclusion] Antibiotic-associated gastrointestinal microflora disorders may be the main cause of pseudomembranous enterocolitis. Proper application of antibiotics and restoration of the imbalanced flora in the intestine may be the major therapy for pseudomembranous enterocolitis.
出处 《中国中西医结合消化杂志》 CAS 2012年第1期7-9,共3页 Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词 肠炎 伪膜性 菌群失调 抗生素 colits,pseudomembrane dysbacteriosis antibiotics
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参考文献4

  • 1HURLEY B W, NGUYEN C C. The spectrum of pse- udomembranous enterocolitis and antibiotic-associated diarrhea[J]. Arch Intern Med, 2002,162 : 2177--2184.
  • 2SONG H J,KIM J Y,JUNG S A,et al. Effect of probi- otic Lactobacillus for the prevention of antibiotic-asso- ciated diarrhea: a prospective, randomized, double- blind,multicenter study[J]. J Korean Med Sci, 2010, 25 : 1784-- 1791.
  • 3SURAWICZ C M, MCFARLAND L V. Pseudomembr- anous colitis caused by C. difficile[J]. Curr Treat Op- tions Gastroenterol, 2000,3 : 203-- 210.
  • 4MONSCHEIN M. C. difficile.-new bacterial species sig nificantly more pathogenic[J]. Kinderkrankenschwest er, 2010,29 :522-- 522.

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