期刊文献+

抗血小板药物治疗的药学监护 被引量:6

Pharmaceutical Care during Antiplatelet Therapies
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摘要 目的:抗血小板药物围绕血栓形成机制,对血小板聚集各个环节形成抑制而成为对抗血栓的一线用药,受到临床医师和患者的青睐,本文总结抗血小板药的临床应用评价和监护要点。方法:采用国内、外文献综述方法。结果与结论:在大量的临床研究中,抗血小板药显示了良好效果,各种临床结果已被多项循证医学系统研究所证实,但其用药风险和不良反应较大,使得药学监护和抗凝药合理安全应用尤显重要。 Objective:To summarize the evaluation of clinical application of antiplatelet drugs and the critical points of pharmaceutical care so as to provide reference for improving the clinical pharmaceutical care.Methods:To collect medical data by literature review both at home and abroad.Results and Conclusion:Antiplatelet drugs were proved good in efficacy by indication-based medical studies and the results of clinical trials were confirmed by clinical systematic researches using multiple evidence-based methodology.As there were potential risks in use of antiplatelet drugs and relatively more adverse drug reactions,the pharmaceutical care and rational use of anticoagulant drugs were becoming more important.
作者 张石革
出处 《中国执业药师》 CAS 2012年第1期4-8,共5页 China Licensed Pharmacist
关键词 抗血小板药 环氧合酶抑制剂 血栓 药学监护 合理用药 Antiplatelet Drug Cyclooxygenase Inhibitor Thrombosis Pharmaceutical Care Rational Drug Use
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参考文献19

  • 1Ruland S.Safety of clopidogrel and aspirin for stroke prevention: implications of the CHARISMA trial[J].Drug Saf, 2008,31 (6) : 449-458.
  • 2Farid NA, Kurihara A, SA, Wrighton SA. Metablism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogel,and prasugrel in humans [J]. J Clin Pharm,2010,50 (2) : 126-142.
  • 3Seto AC, Kenyon K, Wittkowsky AK. Discrepancies in identification of major bleeding events in patients taking warfarin [J]. Pharmacotherapy, 2008,28 (9) : 1098-1112.
  • 4Biondi Zoccai GG, Valgimigli M, Sheiban I, et al. A randomized trial comparing eptifibatide vs placebo in patients with diffuse coronary artery disease undergoing drug-eluting stent implantation: design of the 1Ntegrilin plus STenting to Avoid myocardial Necrosis Trial[J]. J Cardiovasc Med (Hagerstown), 2008,9 (9): 957-962.
  • 5Orford JL, Fasseas P, Melby S, et al. Safety and efficacy of aspirin, clopidogrel, and warfarin after coronary stent placement in patients with an indication for anticoagulation[J].Am Heart J, 2004, 147 (3) : 463-467.
  • 6Mukherjee D, Topoi EJ, Molitemo DJ, et al. Extracardiac vascular disease and effectiveness of sustained clopidogrel treatment[J]. Heart, 2006, 92 (1) .. 49-51.
  • 7Wivio tt SD, Braunwald E, Mccabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes, for the TRITON-T1MI38 in investigators[J]. N Engl J Med, 2007,357 (20) : 2001-2015.
  • 8Hermosillo AJ, Spinier SA. Aspirin, elopidogrel, and warfarin: is the combination appropriate and effective or inappropriate and too dangerous?[J]. Ann Pharmacother, 2008,42 (6) : 790-805.
  • 9Antithrombitic trialists collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients [J]. BMJ, 2002, 324 (7329) : 71-76.
  • 10中国国家处方集编委会.中国国家处方集[M].北京:人民军医出版社,2010:810.

二级参考文献11

  • 1Collet JP, Hulot JS, Pena A, et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction : a cohort study [ J ]. Lancet, 2009,373 (9 660) :309.
  • 2Mega JL, Close SL, Wiviott SD, et al. Cytochrome P- 450 polymorphisms and response to clopidogrel [ J ]. N Engl J Med,2009,360(4):354.
  • 3Simon T, Verstuyft C, Mary- Krause M, et al. Geneti determinants of response to clopidogrel and cardiovascular events[J]. N Engl J Med ,2009,360(4) :363.
  • 4Sibbing D, Stegherr J, Latz W, et al. Cytochrome P450 2C19 loss- of- function polymorphism and stent thrombosis following percutaneous coronary intervention[J]. Eur Heart J, 2009,30(8) :916.
  • 5Angiolillo D J, Fernandez - Ortiz A, Bemardo E, et al. PIA polymorphism and platelet reactivity following clopidogrel loading dose in patients undergoing coronary stent implantation [ J] . Blood Coagul Fibrinol~'sis, 2004,15 ( 1 ) : 89.
  • 6Nguyen TA, Diodati JG, Pharand C. Resistance to clopidogrel: A review of the evidence[J].J Am Coll Cardiol, 2005,45(8) :1 157.
  • 7Chen L, Qin S, Xie J, et al. Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of China's Mainland [ J ] . Pharmacogenomics, 2008,9(6) :691.
  • 8Garcia- Barcelo M, Chow LY, Kum Chiu HF, et al. Frequencies of defective CYP2C19 alleles in a Hong Kong Chinese population [ J ]. Clinical Chemistry, 1999,45 ( 12 ) : 2 273.
  • 9Roden DM, Stein CM. Clopidogrel and the Concept of High - Risk Pharmacokinetics [ J ]. Circulation, 2009, 119 ( 16 ) : 2 127.
  • 10EMEA issues warning on possible clopidogrel - PPI interaction, but is there really a problem [ EB/OL] ? Http :// www. theheart, org/article/98077, do.

共引文献42

同被引文献72

  • 1沈鸿.注射用泮托拉唑钠的配伍稳定性考察[J].安徽医药,2005,9(3):211-212. 被引量:21
  • 2高润霖,钱杰,Charles H Hennekens.预防心血管疾病:中国需要更广泛和正确地使用阿司匹林[J].中国实用内科杂志,2007,27(1):78-81. 被引量:25
  • 3沈杨,辛华雯,李罄,余爱荣.喹诺酮类药物致过敏性紫癜病例分析[J].药物流行病学杂志,2007,16(1):22-24. 被引量:5
  • 4任经天.浅谈我国药品上市后临床研究的监管[J].中国药物警戒,2007,4(2):68-74. 被引量:7
  • 5Kuzniatsova N,Shantsila E, Blann A, et al. A contemporary view- point on "aspirin resistance" [J]. Ann Med, 2012,44(8) :773 - 783.
  • 6Fitzgerald R, Pirmohamed M. Aspirin resistance:effect of clinical, biochemical and genetic factors [ J ]. Pharmacol Ther, 2011,130 (2) :213 -225.
  • 7Vane JR, Bakhle YS, Botting RM. Cyclooxygenases 1 and 2 [ J ]. Annu Rev Pharmacol Toxicol,1998,38( 18 ) :97 -120.
  • 8Berger JS, Brown DL, Becker RC. Low-dose aspirin in patients with stable cartdiovascular disease: a meta-analysis [ J ]. Am J Med, 2008,121 ( 1 ) :43 - 49.
  • 9Yansuf O, Bhatt DL. The evolution of antiplatelet therapy in cardio- vascular disease [ J ]. Nat Rev Cardio1,2011,8 ( 10 ) :547 - 559.
  • 10Baigent C, Blaekwell L, Collins R, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta- analysis of in dividual participant data from randomised trials[ J]. Lancet,2009,373 (9678) : 1849 - 1860.

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