摘要
目的:研究健康人口服奥硝唑片的药代动力学特征。方法:12名健康志愿者单剂量口服奥硝唑片1g,分别在服药后0、0.5、1、1.5、2、3、4、6、8、10、12、24、48、72h时取静脉血3mL,分离血浆,采用HPLC测定奥硝唑的血药浓度,以3p97程序软件计算药代动力学参数。结果:药动学参数表明,奥硝唑人体内过程符合一室模型,Cmax,T1/2(Ke),Tpeak,AUC0-∞分别为(20.55±3.02)mg/L,(15.61±1.87)h,(0.76±1.18)h,(474.07±63.21)mg·h/L。结论:奥硝唑口服吸收快,消除半衰期长。
Objective:To study the pharmacokinetics of ornidazole tablets in healthy volunteers.Methods:Twelve volunteers received a single dose of 1 g ornidazole Tablets,3 mL of venous blood was collected respectively at 0,0.5,1,1.5,2,3,4,6,8,10,12,24,48 and 72 h after the drug administration.The plasma was separated to determine the concentrations of ornidazole by HPLC,and the pharmacokinetics parameter of ornidazole was calculated by 3p97 software.Results:The pharmacokinetic parameters showed that the course in human body of ornidazole was in accordance with the one compartment model.Cmax,T1/2(Ke),Tpeak and AUC0-∞ was(20.55 ±3.02) mg/L,(15.61 ±1.87) h,(0.76 ±1.18) h and(474.07 ± 63.21) mg·h/L respectively.Conclusion:Ornidazole can be rapidly absorbed orally with a longer eliminate half-life.
出处
《中国执业药师》
CAS
2012年第1期12-14,共3页
China Licensed Pharmacist