健康人口服奥硝唑片的药代动力学研究

The Study of Pharmacokinetics of Ornidazole Tablets in Healthy Volunteers

目的:研究健康人口服奥硝唑片的药代动力学特征。方法:12名健康志愿者单剂量口服奥硝唑片1g,分别在服药后0、0.5、1、1.5、2、3、4、6、8、10、12、24、48、72h时取静脉血3mL,分离血浆,采用HPLC测定奥硝唑的血药浓度,以3p97程序软件计算药代动力学参数。结果:药动学参数表明,奥硝唑人体内过程符合一室模型,Cmax,T1/2(Ke),Tpeak,AUC0-∞分别为(20.55±3.02)mg/L,(15.61±1.87)h,(0.76±1.18)h,(474.07±63.21)mg·h/L。结论:奥硝唑口服吸收快,消除半衰期长。

Objective：To study the pharmacokinetics of ornidazole tablets in healthy volunteers.Methods：Twelve volunteers received a single dose of 1 g ornidazole Tablets,3 mL of venous blood was collected respectively at 0,0.5,1,1.5,2,3,4,6,8,10,12,24,48 and 72 h after the drug administration.The plasma was separated to determine the concentrations of ornidazole by HPLC,and the pharmacokinetics parameter of ornidazole was calculated by 3p97 software.Results：The pharmacokinetic parameters showed that the course in human body of ornidazole was in accordance with the one compartment model.Cmax,T1/2（Ke）,Tpeak and AUC0-∞ was（20.55 ±3.02） mg/L,（15.61 ±1.87） h,（0.76 ±1.18） h and（474.07 ± 63.21） mg·h/L respectively.Conclusion：Ornidazole can be rapidly absorbed orally with a longer eliminate half-life.