摘要
目的:在保证丹参滴注液质量标准对原有丹参素钠和原儿茶醛等指标含量要求的前提下,提高丹酚酸B新增指标的含量。方法:采用正交试验方法,优化碱处理工艺的相关参数。结果:最佳碱处理条件为A2B2,即pH7.0～7.5,煮沸30min。结论:最佳A2B2条件能够减少丹酚酸B的过度降解,使丹酚酸B在丹参滴注液中含量相对较高。
Objective：To increase the content of the newly added indicator of salianolic acid B on the premise of ensuring the contents of sodium danshensu and protocatechuic aldehyde according to the quality standards of Danshen drip liquid.Methods：To optimize the parameters of the process of alkali treatment through orthogonal experiment.Results：The optimized alkali treatment condition was A2B2（pH 7.0 ~ 7.5,boiling for 30 mins）.Conclusion：The optimized condition of A2B2 can reduce the over-degradation of salianolic acid B,thus the relatively high content of salianolic acid B in Danshen drip liquid can be obtained.
出处
《中国执业药师》
CAS
2012年第1期15-19,共5页
China Licensed Pharmacist
关键词
丹参滴注液
丹酚酸B
碱处理
热稳定性
正交试验
Danshen Drip Liquid
Salvianolic Acid B
Alkali Treatment
Thermal Stability
Orthogonal Test
