我院333例药品不良反应/事件报告分析

Analysis of 333 ADR/ADE Case Reports in Hospital

目的:分析药品不良反应/事件(ADR/ADE)的发生情况、发生特点及相关因素。方法:收集我院2010年7-12月上报的333例ADR/ADE报告,按照国家ADR监测中心制定的标准进行分析,总结ADR/ADE的发生状况。结果:ADR/ADE报告中,抗感染药引起的ADR/ADE最多,其次为抗肿瘤药、中成药、循环系统用药;给药途径以静脉滴注为主;临床表现以皮肤及其附件损害最常见。结论:应加强对抗感染药和静脉给药方式的监测,减少ADR/ADE的发生。

Objective：To analyze the occurrence,characteristics and related factors of adverse drug reactions/adverse drug events（ADRs/ADEs）.Methods：333 ADRs/ADEs case reports occurred in our hospital from July to December of 2010 were collected and analyzed according to the national standards set by ADR Monitoring Center.Results：Anti-infective agents were the most commonly used drugs in the ADRs/ADEs case reports followed by antineoplastic agents,Chinese patent medicine and circulation drugs.Most ADRs/ADEs were induced by intravenous drip infusion,and skin and its accessory damage were the most presented in ADRs/ADEs.Conclusion：Anti-infective agents and intravenous administration should be monitored to reduce the occurrence of ADR/ADE.