Th9细胞亚群在变态反应性疾病中的作用

The Role of Th9 Cell Subset in the Allergic Diseases

T细胞是免疫系统启动特异性免疫应答以抵御外界病原体入侵的核心力量之一,其免疫功能的发挥依赖于不同环境下的不同分化条件及功能状态。自1986年Mossman和Coffman首次报道了Th1与Th2细胞亚群以来,人们先后又发现了Th17、Th22以及Treg细胞亚群。过去人们一直认为IL-9属于Th2类细胞因子,可作用于多种炎症细胞和组织细胞,在对抗寄生虫感染和诱导变态反应性疾病中发挥着重要的作用。近年研究发现,机体内可能存在着一群新型的CD4+Th细胞亚群,具有分泌IL-9和IL-10的能力,有学者称之为"Th9"细胞。Th9细胞亚群在变态反应性疾病中所起的作用还不十分清楚,本文将对这一细胞亚群在慢性变态反应性疾病中发挥的作用作一阐述。

T cells were the core strength to fight against the invading pathogens in the immune system. The specific immune response of T cells depended on the different circumstances, conditions and functional status. Since Mossman and Coffman first reported Th1 and Th2 cell subsets in 1986, people have discovered Th17, Th22 and Treg cell subsets. The cytokine IL-9 has largely been regarded as a Th2 cytokine that makes important contributions to parasite diseases and allergic diseases. Recent data suggested that under certain conditions, a distinct CD4 ＋ Th population producing IL-9 and IL-10 called ＂Th9＂may exist. The function of Th9 cells in allergic diseases is still currently unknown and this article will make a review for how these cells may regulate chronic allergic inflammation.