羟基喜树碱联合放疗治疗晚期宫颈癌的疗效观察

Observation on hydroxyl camptothecin combined with radiotherapy for treating advanced cervical cancer

目的观察羟基喜树碱(hydroxy camptothecin,HCPT)联合放疗治疗晚期宫颈癌的近期疗效及不良反应。方法 37例Ⅲ期宫颈癌患者随机分为综合治疗组和单纯放疗组,行同期对比分析。综合治疗组在放疗的第一周和第四周每日放疗后加用HCPT 10 mg/d,每周连用5 d。结果放疗结束时综合治疗组总有效率较单纯放疗组高,差异有统计学意义(P<0.05)。放疗后3个月,两组总有效率差异仍有统计学意义(P<0.05),不良反应差异无统计学意义(P>0.05)。结论 HCPT联合放疗能提高晚期宫颈癌患者近期疗效,且不增加不良反应。

Objective To observe the short-term curative effects and adverse reactions of hydroxyl camptothecin（HCPT） combined with radiotherapy on advanced cervical cancer and to investigate the application value of HCPT as an inhibitor of DNA topoisomerase I in treating cervical cancer.Methods 37 patients with stage Ⅲ cervical cancer were randomized into the synthesis group（HCPT plus radiotherapy group） and only radiotherapy group.The synthesis group was given the same radiation dosage plus HCPT 10mg/d in the first and fourth weeks after radiotherapy.Results After radiotherapy,the total effective rates were higher in the synthesis group than in the only radiotherapy group with statistical difference（P0.05）.In 3 months after radiotherapy,the total effective rates still showed significant difference（P0.05）.The adverse reactions had no apparent difference between the two groups.Conclusion HCPT combined with radiotherapy can improve the short-term therapeutic efficacy of advanced cervical cancer without increasing adverse reactions.