坚肾合剂对Adenine所致CRF大鼠血NO、NOS及TNF-α的影响

The Levels of NO,NOS and TNF-α in Blood of CRF Rats Induced by Adenine after Treated by Jianshen Mixture

探讨腺嘌呤致大鼠慢性肾衰模型中血NO、NOS及TNFα变化及坚肾合剂的治疗作用。结果:坚肾合剂可显著降低CRF大鼠24h 尿蛋白,改善肾功能作用接近尿毒清;在升高NO、降低TNFα方面,坚肾合剂明显优于尿毒清。

The levels of NO,NOS and TNF α of blood were investigated in CRF rats after treatment with Jianshen mixture.The result showed that Jianshen mixture could obviously decrease the content of urinary proteins within 24h in CRF rats,and improve renal function.The effect was closed to Niaoduqing.Jianshen mixture was better than Niaoduqing in increasing of NO and decreasing of TNF α concentrations in CRF rat's blood.