聚丙烯酰胺水凝胶生物性能的实验研究

Experimental study on biological properties of polyacrylamide

为了准确掌握从乌克兰和俄罗斯引进的两种聚丙烯酰胺的性质、特点 ,使其更好地应用于临床患者 ,我们将其分别注射于小白鼠和大白鼠的皮下 ,并均用硅凝胶作对照 ,注射后 3、7、15、3 0天作肉眼观察和组织切片观察 ,得出乌克兰聚丙烯酰胺在机体内引起的炎症反应明显较硅凝胶小 ,包囊也薄 ,囊周无明显的肉芽组织形成。故该材料是组织相容性好 ,无毒副作用 ,不吸收的最新组织填充材料 ,明显优于硅凝胶。而俄罗斯产聚丙烯酰胺引起的组织学反应与硅凝胶相似 ,故应用于临床尚需慎重。

To master exactly the Ukrainian and Russian polyacrylamide is the key point for its better use in clinic. They were injected under the dermis of rats and Wistar rats and silica gel was used in the control group. After 3、7、15、30 days, naked eye and microscopic study were made. Ukrainian polyacrylamide induced less inflammatory reaction than silica gel as well as the capsule was thinner. No pericapsular granulation tissue was formed. Russian polyacrylamide induced tissue reaction similar to silica gel. Ukrainian polyacrylamide has better tissue compatibility, no toxicity and no absorption thus superior to silica gel. Russian polyacrylamide must be used cautiously in clinic.