摘要
目的探讨血清白细胞介素17(IL-17)和肿瘤坏死因子仪(TNF-α)及滑膜病变检测在类风湿关节炎(RA)患者中的临床意义。方法应用酶联免疫吸附测定法(EuSA)对50例活动期RA患者(活动期RA组)、50例稳定期RA患者(稳定期RA组)和50例体检健康者(健康对照组)血清IL-17和TNF-α水平进行检测,同时取其关节滑膜进行病理检查。结果活动期RA组血清IL-17和TNF-α水平[(42.60±11.30)、(113.20±13.11)mg/L]明显高于稳定期RA组[(19.60±5.75)、(14.50±5.33)mg/L]和健康对照组[(7.40±3.32)、(10.90±2.24)mg/L](P〈0.01);稳定期RA组血清IL-17水平高于健康对照组(P〈0.05),而TNF-α水平与健康对照组比较差异无统计学意义(P〉0.05)。RA患者的滑膜与健康对照组相比呈明显的病态。结论RA患者血清IL-17和TNF-α水平及滑膜病变的变化特点与病情有关,联合动态监测有助于临床观察和治疗。
Objective To investigate the levels of serum interleukin -17(IL-17) and tumor necrosis factor -alpha(TNF-α) and synovium pathological changes in patients with rheumatoid arthritis (RA) and its clinical significance. Methods The levels of serum IL-17 and TNF-α in 50 patients with active phase of RA (active phase of RA group) ,50 patients with stable phase of RA (stable phase of RA group) and 50 normal controls (NC group ) were measured by enzyme-linked immunospecific assay(ELISA ), and the synovium was detected by pathological examination. Results The levels of serum IL-17 and TNF-α in active phase of RA group [ (42.60 ± 11.30), ( 113.20 ± 13.11 ) mg/L ] were significantly higher than those in stable phase of RA group [ ( 19.60 ± 5.75), ( 14.50 ±5.33 ) mg/L] and NC group [ (7.40 ± 3.32), ( 10.90 ± 2.24) mg/L] (P 〈 0.01 ), the level of serum IL-17 in stable phase of RA group was significantly higher than that in NC group (P 〈 0.05), but the level of TNF-α had no significant difference between stable phase of RA group and NC group (P 〉 0.05 ). The synovium was significantly different between RA patients and NC group. Conclusion IL-17 and TNF-α are more sensitive index for detecting the activity of RA and may play important roles in monitoring the therapeutic effects and prognosis of RA.
出处
《中国医师进修杂志》
2012年第2期14-16,共3页
Chinese Journal of Postgraduates of Medicine
关键词
关节炎
类风湿
白细胞介素17
肿瘤坏死因子Α
滑膜病变
Arthritis, rheumatoid
Interleukin-17
Tumor necrosis factor-alpha
Synovium pathological changes