肥胖矛盾现象及其对治疗的启示

Obesity Paradox Phenomenon and its Enlightenment on Treatment

肥胖是目前全球性最大的慢性病,它既是多种心血管与代谢病的主要危险因素,也是重要的致病因子。肥胖与高血压、高血脂、糖尿病等密切相关,相互重叠增加心血管疾病的患病率。近年来研究发现体重指数与心血管预后及靶器官损害呈负相关,有学者将肥胖与心血管死亡率的矛盾现象称为肥胖矛盾。这种现象的出现引起了人们的关注,探讨其发生的可能机制对未来心血管疾病的治疗提供了一个新的启示。

Obesity is the biggest global health problem; it is not only the primary risk factors, but also important virulence factor of cardiovascular disease. Obesity is closely related with hypertension, elevated levels of blood lipid and diabetes, and is responsible for the increment of heart disease occurrence rate. Recent studies have found that body mass index and cardiovascular prognosis and target organ damage were negatively correlated, the phenomenon of obesity and cardiovascular mortality paradox are known as obesity paradox. This contradiction has caused the attention; further researches on mechanisms of obesity paradox will bring a kind of new way for the treatment of cardiovascular disease.