益肾降浊汤对慢性肾功能衰竭模型小鼠肾功能影响的实验研究

The Effect of Yishen Jiangzhuo Decoction on Renal Function of Mice with Chronic Renal Failure

目的:观察益肾降浊汤对腺嘌呤引起的慢性肾功能衰竭小鼠的治疗作用。方法:以腺嘌呤诱导小鼠慢性肾功能衰竭模型,予以益肾降浊汤治疗28天。测定血清尿素氮、肌酐、血磷、血钙、胆固醇、甘油三酯、尿酸、体质量、肾脏系数等指标。取肾脏做病理学检查。结果:与模型组比较,益肾降浊汤高、中、低剂量组和尿毒清组可明显降低血中尿素氮、肌酐、磷、胆固醇、甘油三酯水平,升高血钙水平,病理学显示模型小鼠肾脏损害减轻。结论:益肾降浊汤对腺嘌呤导致的慢性肾功能衰竭小鼠有一定的治疗作用。

Objective：To observe the effect of Yishen Jiangzhuo decoction on adenine - induced chronic renal failure in mice. Methods：Mice were fed with adenine to induce chronic renal failure. Yishen Jiangzhuo decoction was given for 28 days, and mice were killed. Detect serum urea nitrogen, creatinine, serum phosphorus, calcium, cholesterol, triglycerides, uric acid, weight, kidney coefficient, etc. And take kidneys for Pathological examinations. Results：Compared with model group, the high, medium and low - dose group of Yishen Jiangzhuo decoction and Niaoduqing group could lower the serum urea nitrogen, creatinine, phosphorus, cholesterol, triglyceride levels, elevate serum calcium levels. And they could reduce kidney damage of the model of mice in Pathology. Conclusion： Yishen Jiangzhuo decoction has a therapeutic effect on mice with chronic renal failure induced by adenine.