血液病致死性医院感染危险因素分析

Approach for the risk factors about lethal nosocomial infection in 510 cases with haematological diseases

目的 为了解血液病致死性医院感染及相关危险因素。方法 回顾分析了 5年来我院血液病住院患者 5 10例有关临床资料。结果 医院感染率为 17.0 5 % ,其中 2 8.7%死亡。在医院感染死亡患者中 ,中性粒细胞 ( PMN)、CD4及 CD8比例显著下降。感染的病原菌以革兰阴性杆菌及念珠菌为主 ,并以下呼吸道及血液感染多见。结论 人体免疫功能极度低下是导致感染死亡的主要内在因素 ,对该类患者应加强防护。

OBJECTIVE In order to study the risk factors of lethal nosocomial infection in patients with haematological diseases .METHOD 510 inpatients with haematological diseases from October 1993 to January 1998 were retrospectively analyzed.RESULTS The total infection rate were 17.05%.28.7% of all patients who suffered from nosocomial infection died of the disease . Serious granulocytopenia,lower CD4 and ratio of CD4/CD8 were found in the course of infection and the predominant pathogens were Gram negative bacteria and Candida albicans.Septiceimia and pneumonia were seem more frequently in those patients.CONCLUSION Our results indicate that secondary immunity deficiency may be the internal cause of lethal nosocomial infection and the protective measures should be seriously considered for them.