摘要
目的:探讨血清SOD及NO在小儿喘息性疾病中的作用以及血清值变化情况。方法:收治小儿喘息性疾病患儿60例,分为毛细支气管炎组、喘息性支气管炎组及支气管哮喘组3组,每组各20例,选择同期市妇幼保健院健康查体儿童20例为对照组。分析4组SOD和NO值,4组间数据采用方差分析进行统计分析(检验水平α=0.05)。结果:毛细支气管炎组、喘息性支气管炎组、支气管哮喘组,患儿急性期、恢复期SOD值均低于对照组健康儿童,差异具有统计学意义(急性期P<0.001,恢复期P<0.001),但毛细支气管炎组、喘息性支气管炎组、支气管哮喘组,患儿急性期、恢复期NO值均高于对照组健康儿童,差异具有统计学意义(急性期P<0.006,恢复期P<0.035)。结论:SOD和NO值在小儿喘息性疾病中的变化,有明显临床意义,通过进一步研究SOD和NO值的变化对小儿喘息性疾病的发展、转归有临床指导意义。
Objective:To investigate immunoregulatory role of SOD and NO for asthmatic disease in infants and its change in the levels of in blood serum.Methods:SOD and NO were measured by ELISA in 60 infants with asthmatic disease,who were divided into bronchiolitis group,asthmatic bronchitis group and bronchial asthma group,with 20 infants in each group and another 20 infants as healthy controls.The data were adopted analysis of variance to being statistical analyse.Results:During the acute phase and recovery phase of bronchiolitis group,asthmatic bronchitis group and bronchial asthma group,the levels of SOD were lower than those in controls,showed significant difference when compared with the controls(acute phase P0.001,recovery phase P0.001).While the acute phase and recovery phase of asthmatic disease,the levels of NO were higher than those in controls,showed significant difference when compared with the controls(acute phase P0.006,recovery phase P0.035).Conclusion:The change in the levels of SOD and NO in blood serum was remarkable clinical sense in infant with asthmatic disease.Access to go a step further researcher about SOD and NO'changes in the levels of in blood serum,there is a sense guiding clinic in development and recovery of infantile asthmatic disease.