注射用阿奇霉素与红霉素随机对照治疗下呼吸道细菌感染的临床评价

EVALUATION OF THE EFFICACY AND SAFETY OF INJECTABLE AZITHROMYCIN AND ERYTHROMYCIN IN TREATMENT OFLOWER RESPIRATORY TRACT INFECTION

目的 :评价注射用阿齐霉素治疗下呼吸道细菌感染的临床疗效及其安全性。方法 :采用随机对照多中心分组研究方法 ,比较阿齐霉素 ( 5 0 0mg ,静滴 ,qd ,疗程 5～ 7d)与红霉素 ( 5 0 0mg ,静滴 ,bid ,疗程 5～ 7d)治疗下呼吸道感染的疗效。结果 :阿齐霉素组的痊愈率和总有效率分别为 61.7%和 93 .3 % ,细菌清除率为 96.7% ,不良反应发生率为 13 .3 % ;而红霉素组的痊愈率和总有效率分别为 3 5 .0 %和 71.7% ,细菌清除率为 78.3 % ,不良反应发生率为 4 0 .0 %。结论 :阿齐霉素的临床疗效、细菌清除率和安全性均明显优于红霉素。

OBJECTIVE:To evaluate the efficacy and safety of injectable azithromycin and erythromycin in treatment of lower respiratory bacterial infections. MEHTODS:A randomized controlled multicenter clinical study was used to compare the clinical efficacy of azithromycin and erythromycin, and a regimen of 500 mg/d for 5～7 days was used for both agents. RESULTS:The cure rate, effective rate, and bacterial clearance rate obtained were 61.7%, 93.3%, and 96.7% respectively for azithromycin group and were 35.0%, 71.7%, and 78.3% respectively for erythromycin group with a side effects incidence of 13.3% for azithromycin group and 40.0% for erythromycin group. CONCLUSION:Azithromycin is superior to erythromycin in clinical efficacy, safety and side effects incidence.