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奈达铂联合紫杉醇治疗晚期食管癌60例临床观察

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摘要 目的:观察奈达铂(NDP)联合紫杉醇治疗晚期食管癌的近期临床疗效和不良反应。方法:60例晚期食管癌患者,随机分为治疗组和对照组,每组各30例。治疗组采用奈达铂(NDP)90mg/mld1~d3联合紫杉醇135mg/ml静滴d1;对照组采用顺铂(DDP)30mg/mld1~d3,5-氟尿嘧啶(5-Fu)500~750mg/ml静滴d1~d5。28天1周期,连续2周期后评价治疗效果,并详细记录不良反应。结果:治疗组有效率67.8%,对照组有效率43.3%,两组有效率比较差异有统计学意义。全部病例均存在不良反应。消化道反应及骨髓抑制等不良反应,治疗组明显轻于对照组,差异有统计学意义(P<0.05)。结论:奈达铂联合紫杉醇治疗晚期食管癌近期临床疗效确切,安全性较好。
作者 陈良峰
出处 《中国社区医师(医学专业)》 2012年第2期88-88,共1页
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