系统性硬皮病患者缺氧与皮肤硬化关系的初探

Investigation of Relationship Between Hypoxia and Sclerosis of Skin in Patients with Systemic Sclerosis

目的 探讨缺氧对系统性硬皮病 (SSc)患者皮肤硬化的影响。方法 测定 SSc患者血氧分压和皮肤硬度积分，对二者进行直线相关分析，并测定低氧 (2.5％氧浓度 )对体外培养的 SSc患者皮肤成纤维细胞增殖的影响。结果 30例 SSc患者血氧分压为 6.38～ 12.06 kPa，平均 (9.53± 1.93)kPa； 20例正常对照组为 (10.67～ 13.33)kPa，平均为 (12.01± 0.81)kPa。前者比后者显著降低 (t=5.276。

Objective To investigate the effects of hypoxia on the sclerosis of the skin in patients with systemic sclerosis (SSc). Methods The arterial oxygen pressure (PO2) was determined and the degree of sclerosis was evaluated in patients with SSc.The Pearson′ s correlation coefficient was used for analyzing the relationship between PO2 and skin sclerosis scores. The effects of 2.5％ and 20％ oxygen concentration on the proliferation of cultured SSc skin fibroblasts were measured. Results The PO2 values in 30 SSc patients were 6.38～ 12.06 kPa (9.53± 1.93 kPa), whereas that in 20 normal controls were 10.67～ 13.33 kPa (12.01± 0.81kPa). The former is significantly lower than that of the latter (t=5.276, P