摘要
目的:评估甲状腺自身抗体(ATA)与反复自然流产(RSA)之间的关联。方法:采用电化学发光法对102例RSA患者血清进行抗甲状腺过氧化酶抗体(TPO-Ab)和抗甲状腺球蛋白抗体(TG-Ab)的检测,并以50例健康育龄妇女为对照。结果:RSA的患者中ATA总阳性率22.6%,明显高于正常对照组8.0%,RSA组中TPO-Ab和TG-Ab的阳性率分别为20.6%和15.7%,均显著高于正常对照组的6.0%和4.0%。早期流产组中的ATA总阳性率27.9%,与晚期流产组比较有明显的统计学上的差异,TPO-Ab和TG-Ab的阳性率分别为25.0%和19.1%,均显著高于正常对照组的11.8%和8.82%。2～3次或以上两组流产患者ATA的阳性率分别为32.4%和26.5%,两组间有统计学上的差异。结论:孕妇甲状腺自身抗体的存在与反复自然流产密切相关,甲状腺自身抗体可作为早期反复自然流产的监测指标。
Objective：To evaluate the relationship between thyroid antibodies（ATA）and repeated natural abortion （RSA）.Methods：Test the thyroid peroxidase antibodies（TPO-Ab）and antithyroglobulin antibody（TG-Ab）in 102 cases of RSA patients＇ serum using the method of electrochemical luminescence,keep 50 cases of healthy child-bearing age women as controls.Results：The total ATA positive rate in the patients of RSA was 22.6%,which is apparently 8.0% higher than the control group,TPO-and TG Ab-Ab positive rate in the RSA group were 20.6% and 15.7% respectively,both significantly higher than the 6.0% and 4.0%in the control group.the total positive rate ATA was 27.9% in the early abortion group,which was statistically significant different from that of the late abortion group,positive rate of TPO-Ab and TG-Ab were 25.0% and 19.1% respectively,significantly higher than the 11.8% and 8.82% than that of the normal control group.The positive rate of ATA patients of twice-abortion group was 32.4 and for the three or more than three-time sabortion group was 26.5%.there＇s statistical differences between the two groups.Conclusion：The repeated natural abortion closely related to the existence of pregnant women＇s thyroid antibodies,the thyroid antibodies can be the monitoring index to the early repeated natural abortion.
