妊高征患者血浆和胎盘中环磷酸鸟苷浓度的变化及其意义

The Changes and Their Significance of Plasma and Placental Tissue cGMP in Patients with Pregnancy Induced Hypertension

目的 探讨环磷酸鸟苷 (c GMP)在妊高征发病中的作用。 方法 采用放射免疫法测定 12 4例正常妊娠各期、32例妊高征患者及 30例健康对照者血浆 c GMP浓度。其中 32例正常足月孕妇和 32例妊高征患者于剖宫产时取胎盘组织测其匀浆 c GMP浓度。 结果 (1)正常妊娠各期血浆 c GMP(2 6 .2 5± 4.30 )、(2 3.40± 4.5 4)、(2 6 .2 0± 6 .6 0 )、(34 .14± 8.41)、(32 .32± 8.11) nm ol/ L 显著高于健康对照者 (2 0 .2 2± 3.44 ) nm ol/ L (P均 <0 .0 5 )。 (2 )妊高征血浆及胎盘 c GMP(2 8.49± 8.98) ) nmol/ L与 (2 .76± 0 .49) nmol/ g均显著低于正常足月孕妇 (34 .14± 8.41) nmol/ L与(3.78± 0 .81) nmol/ g(P<0 .0 5 ,P<0 .0 0 1)。轻度妊高征患者血浆及胎盘 c GMP显著高于中度及重度患者 (P<0 .0 0 5 ,P<0 .0 5及 P<0 .0 5 ,P<0 .0 0 1)。妊高征患者血浆及胎盘 c GMP与舒张压均呈负相关 (P<0 .0 5 ,P<0 .0 5 )。 (3)妊高征患者胎盘 c GMP显著低于其血浆 c GMP(P<0 .0 0 1)。 结论 妊娠期间胎盘产生的 c

Objective To determine the effects of cGMP on the pathogenesis of pregnancy induced hypertension(PIH). Methods The plasma of 124 normal pregnancy, 32 cases of PIH and 30 cases of healthy non pregnant women were studied, and the placental tissue cGMP level of 32 mormal pregnancies and 32 PIH were measured by radioimmunoassay (RIA). Results (1) The plasma cGMP level in normal pregnancy (26 25±4 30),(23 40±4 54),(26 20±6 60),(34 14±8 41),(32 32±8 11) nmol/L,was increased significantly as compared with that of healthy non pregnant women ( P <0.05). (2) The plasma and placental tissue cGMP level in PIH was lower than that of the normal pregnancy (28 49±8.98 vs 34.14±8.41) nmol/L and (3.78±0.81 vs 2.76± 0.49) nmol/g P <0.05 and 0.001, respectively. The cGMP levels in plasma and placental tissue were significantly different between the mild and the moderate and between the mild and severe PIH (P<0.005, P<0.05, or P<0.05, P<0.001, respectively). A negative correlation was seen between the plasma level or the placental tissue cGMP level and diastolic blood pressure in PIH (P<0.05, P<0.05, respectively). (3) The placental tissue cGMP was lower than that of the plasma cGMP in pIH (P<0.001). Conclusions The placental tissue cGMP may play an important role in the pathogenesis of PIH.