乙酰螺旋霉素治疗孕期弓形虫感染62例临床疗效观察

The clinical evaluation of curative effect of acetylspiramycin on toxoplasmosis infection during pregnancy.

目的 观察乙酰螺旋霉素治疗孕期弓形虫 (Tox)感染的临床疗效。方法 治疗组 6 2例弓形虫活动性感染孕妇和育龄妇女给予口服乙酰螺旋霉素 0 .5g ,6小时 1次 ,共服 10天 ,另选择 2 0例弓形虫活动性感染育龄妇女未给任何治疗作为对照 ,比较两组弓形虫特异性IgM抗体的转阴率。 结果 治疗组 2 9例孕妇和 33例育龄妇女Tox -IgM的转阴率分别为 86 .2 %和 84.8% ,而对照组的自然转阴率为 15 % ,经统计学检验两者均与对照组有非常显著性差异 (P <0 .0 1)。 3例羊水PCR检测Tox -DNA为阳性的胎儿治疗后检测其脐血Tox -DNA ,2例转阴。随访 6例乙酰螺旋霉素治疗后出生的新生儿 ,未发现明显异常。结论 乙酰螺旋霉素是孕期抗弓形虫感染的安全有效的药物。

Objective\ To investigate the curative effect of the acetylspiramycin on toxoplasmosis infection during pregnancy.Methods\ In treatment group,62 pregnant and child-bearing age women with toxoplasmosis IgM antibody(Tox-IgM)positive were given acetylspiramycin 0.5g/6h for 10 days,while 20 child-bearing age ones were given nothing at all as a control.The negative rates of the Tox-IgM in the two groups were compared statistically after the treatment.Results\ Compared with the 15% negative rate in the control group,the negative rates of the Tox-IgM in 29 pregnant women and 33 child-bearing age women were 86.2% and 84.8% respectively,there was significant difference between the two groups(P<0.01).After being treated with acetylspiramycin,2 newborn were found Tox-DNA negative in umbilical blood out of 3 fetus with amniotic fluid Tox-DNA positive.Conclusion\ Acetylspiramycin was a safe and effective chemical medicine in treating toxoplasmosis infection during pregnancy.