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Endophilin-A1的功能和作用机制及与认知功能的关系

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摘要 最近国内外研究提示endophilin-A1在多种认知功能损害性疾病,如阿尔茨海默病(AD)和糖尿病认知功能损害中异常表达。Endophilin-A1是一种广泛表达于脑的突触前神经终末的胞浆蛋白,在突触囊泡的内吞回收,尤其是网格蛋白介导的囊泡内吞(CMVE)过程中起重要作用。研究认为其本身可能调节Aβ的生成,也可能通过CMVE来影响脑内Aβ的生成与释放,提示其与AD的发病有关。此外,endophilin-A1在糖尿病认知功能损害的大鼠脑内表达下调。本文就近年来endophilin-A1的研究进展作一综述。
作者 罗峥 徐晓云
机构地区 同济大学附属上海市东方医院神经内科
出处 《国际神经病学神经外科学杂志》 2011年第6期557-560,共4页 Journal of International Neurology and Neurosurgery
关键词 Endophilin-A1 突触囊泡 网格蛋白介导的内吞 认知损害
分类号 R749.1 [医药卫生—神经病学与精神病学]
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参考文献23

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国际神经病学神经外科学杂志
2011年 第6期

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