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DNA拷贝数变异与神经系统疾病相关性研究进展 被引量：2

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摘要 DNA拷贝数变异(CNVs)是指与基因组参考序列相比,DNA片段大小范围从kb到Mb的亚微观突变。近年来CNVs作为一种新的疾病易感标志的DNA多态性,其变异引起的基因剂量改变可导致表型的改变,且与很多疾病的发病机制有关,尤其是神经系统疾病,已成为当今研究的热点。本文就CNVs与神经系统疾病的研究进展进行综述,以期为深入研究这类复杂性疾病发病的分子机制和遗传基础提供参考。
作者 李冠男 王建华 杨健
机构地区 首都儿科研究所
出处 《国际神经病学神经外科学杂志》 2011年第6期569-573,共5页 Journal of International Neurology and Neurosurgery
基金 国家自然科学基金(81070491)
关键词 拷贝数变异 神经系统疾病 相关性
分类号 R741 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献31

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共引文献18

同被引文献57

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引证文献2

二级引证文献1

国际神经病学神经外科学杂志
2011年 第6期

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