寻常型银屑病皮损中Stat3和Survivin的表达及相关性分析

The expression of Stat3 and Survivin in the lesions of psoriasis vulgaris and their correlation

目的探讨信号传导及转录活化因子3(Stat3)及生存素(Survivin)在寻常型银屑病皮损中的表达及其相关性。方法通过免疫组化方法研究52例寻常型银屑病皮损中Stat3及Survivin表达的情况,并探讨Stat3和Survivin表达的相关性。结果寻常型银屑病皮损中Stat3的表达和凋亡抑制蛋白Sur-vivin的表达与正常对照组相比均明显上调(P<0.05)。银屑病患者Stat3表达和Survivin表达呈正相关(P<0.01)。结论寻常型银屑病皮损中存在Stat3和Survivin的高表达,Stat3可能通过上调Survivin的表达,促进银屑病皮损处角质形成细胞的增殖,在寻常型银屑病的发生发展中起重要作用。

Objective To investigate the expression of Stat3 and Survivin in the lesions of psoriasis vulgaris and their correlation. Methods The expressions of Star3 and Survivin in 52 patients with psoriasis vulgaris were detected by immunohistochemistry, and the correlation between Star3 and Survivin expression was analyzed. Results The expressions of Stat3 and Survivin were significantly up-regulated, as compared with those in control group（ P 〈 0.05）. The expression of Star3 was positively correlated with that of Survivin in patients with psoriasis vulgaris （ P 〈 0. 01 ）. Conclusion The Star3 and Survivin are over-expressed in psoriasis vulgaris. Survivin can promote the proliferation of keratinocyte in the lesions of psoriasis vulgaris by up-regulating the expression of Survivin, which may play an important role in the pathogenesis and development of psoriasis vulgaris.