生血宁治疗干扰素联合利巴韦林致丙肝患者血细胞减少的疗效观察

Effect of Shengxuening in the treatment of Cytopenia in patients with hepatitis C caused by interferon plus ribavirin therapy

目的观察生血宁治疗干扰素联合利巴韦林致血细胞减少的丙肝患者的疗效。方法选择28例接受聚乙二醇干扰素α-2a联合利巴韦林治疗导致血细胞减少的慢性丙型肝炎患者,予口服生血宁治疗12周,观察治疗前后血红蛋白(Hb)、红细胞计数(RBC)、红细胞压积(Hct)、白细胞计数(WBC)、血小板计数(PLT)的变化以及患者自觉症状的改善情况。结果显效19例(67.85%),有效8例(28.57%),无效1例(3.57%),总有效率为96.43%。治疗后Hb、RBC、Hct、WBC、PLT均显著上升,治疗前后差异均有统计学意义(P<0.01)。结论生血宁治疗聚乙二醇干扰素α-2a联合利巴韦林致血细胞减少的慢性丙型肝炎患者效果明显,可促进红细胞、白细胞及血小板的生成。

Objective To observe the effect of Shengxuening in the treatment of Cytopenia in patients with hepatitis C caused by interferon plus ribavirin therapy.Methods 8 patients of hepatitis C undergoing cytopenia caused by PEG-IFNα2a plus ribavirin therapy were selected and treated by oral intake of Shengxuening for 12 weeks.The changes in the hemoglobin（Hb）,red blood cells（RBC）,hematocrit（Hct）,white blood cells（WBC）,platelet（PLT） levels and the improvements in the subjective symptoms of patients were investigated.Results Of the 28 cases,the treatment was significantly effective in 19 cases（67.85%）,effective in 8 cases（28.57%）,and invalid in 1 case（3.57%）.The total effective rate was 96.43%.The levels of Hb,RBC,Hct,WBC,PLT increased significantly after treatment compared with that before treatment（P0.01）.Conclusion Shengxuening is effective for treating cytopenia caused by PEG-IFNα2a plus ribavirin therapy in patients with hepatitis C,enhancing the formation of erythrocyte,leukocytes and platelets.