血凝酶治疗新生儿上消化道出血疗效分析

Haemocoagulase in the treatment of upper gastrointestinal bleeding of newborn

目的探讨血凝酶治疗新生儿上消化道出血的疗效。方法对2007年1月至2009年6月本院新生儿科病房确诊为新生儿上消化道出血的患儿进行回顾性分析,按患儿出凝血功能正常与否分成A、B两组,在予法莫替丁抑酸治疗原发病及并发症的基础上,再按加用血凝酶与否,进一步分为A1、A2组和B1、B2组,对止血效果进行对比。结果出凝血功能正常的患儿,加用血凝酶治疗与否,出血时间相近,差异无统计学意义(P>0.05);出凝血功能异常患儿,加用血凝酶治疗者出血时间较短,差异有统计学意义(P<0.05)。结论对出凝血功能异常的新生儿上消化道出血,加用血凝酶治疗有效,但对于出凝血功能正常的患儿,加用血凝酶治疗效果不明显。

Objective To evaluate the hemostasia effect of haemocoagulase in upper gastrointestinal bleeding of newborn.Methods We analyzed 103 cases diagnosed with upper gastrointestinal bleeding from Jan.2007 to Jun.2009 and divided them into two groups by blood coagulation function.62 patients in A group with normal blood coagulation function were treated with famotidine,at the same time,control the basic disease,stabilize internal environment.A group were divided into two groups：32 in group A1 received haemocoagulase and 30 in group A2 did not.The other 41 patients with abnormal blood coagulation function were assigned to B group.B group were divided into two groups：22 in group B1 received haemocoagulase and 19 in group B2 did not.Results The patients treated with haemocoagulase or not had no statistically significant differences in the bleeding times in A group.The patients treated with haemocoagulase or not had statistically significant differences in the bleeding times in B group.Conclusion To those patients with abnormal bleeding and coagulating function,haemocoagulase is effective.But to those patients with normal bleeding and coagulating function,haemocoagulase does not increase the efficacy.