摘要
GD3是含唾液酸的神经节糖脂分子,与细胞的多种功能密切相关,在这个过程中包含了细胞凋亡与增殖、细胞分化、信号传导和细胞迁徙等一系列生物行为。本文主要综述了GD3的分子结构,生物学作用,尤其是在肝癌的发生与发展过程的作用及临床研究成果。
The α 2,8-sialyl-transferase,called GD3 synthase,sialic acid-containing glycosphingolipids,has been historically considered to be involved in the proliferation,differentiation,signal transduction and migration of biological behavior in vertebrates.This review summarizes the molecular structure and biological function of GD3 synthase,especially its function in the genesis and progress of hepatic carcinoma.
出处
《海南医学》
CAS
2012年第2期122-124,共3页
Hainan Medical Journal
关键词
GD3
肝癌
NF-KB
GD3 synthase
Hepatic carcinoma
NF-KB
