卡托普利在皮肤缺损治疗中的应用

Effects of Captopril on Skin defect

目的:探讨小剂量卡托普利对中小面积皮肤缺损非植皮治疗的促进作用。方法:按就诊顺序将皮肤缺损直径在2.5～7.5cm的非植皮治疗病例随机分成治疗组17例和对照组14例,治疗组给予卡托普利每次12.5mg,每日晚一次,对照组未予类似药物,比较两组愈合时间的差异。结果:两组病例均以创面直径相差1cm为组距分五个组段,分别计算各组段平均愈合时间,再进行两样本均数比较的t检验,得t=1.7112,0.025<P<0.05,治疗组平均愈合时间明显缩短。

Objective: The authors evaluated the effects of captopril on skin defect's patients without skin grafting. Methods: 31 skin defect's patients (size 2.5~7.5cm) were divided into two groups randomized: experimental group(n=17), control group (n=14). The patients of experimental group had been qiven captopril 12.5mg a day as a single dose in the evening, and the control group hadn't been qiven any analogs, compare the cure time between them. Results: The skin defect's size of these patients in each group were divided into five classifications that the class interulal was 1.0cm , then the authors compute the average cure time of each classifieation. The cure time of experimental group was markedly reduced than that of control group ( P<0.05 ). Conclusions: The result of this study demostrates that captopril in little dosage have marked effcts on skin defect's patients.