布地奈德混悬液联合妥洛特罗贴剂治疗婴幼儿反复喘息的疗效及安全性研究

Efficacy and safety of budesonide suspension fluid combined with tulobuterol tape in treatment of recurrent wheezing in infants and young children

目的探讨布地奈德混悬液雾化吸入和妥洛特罗贴剂联合治疗婴幼儿反复喘息的疗效及安全性。方法选取反复喘息婴幼儿62例,随机分为试验组(n=31)和对照组(n=31)。在喘息临床缓解后稳定期的控制阶段,试验组给予雾化吸入布地奈德混悬液联合妥洛特罗贴剂共12周;对照组给予雾化吸入布地奈德混悬液12周。分别在2、4、6、8、10、12周进行随访,分析患儿咳喘发作、呼吸道感染次数及合并用药情况。结果试验组30例及对照组29例患儿完成了12周的既定治疗方案及随访。试验组咳嗽症状评分、喘息发作次数、喘息症状评分、合并用药评分均低于对照组,差异均有统计学意义(P<0.01);试验组呼吸道感染次数明显少于对照组(P<0.05)。结论布地奈德混悬液雾化吸入和妥洛特罗贴剂联合治疗婴幼儿反复喘息的疗效优于单用布地奈德雾化吸入,且安全性较高。

Objective To evaluate the efficacy and safety of budesonide suspension fluid inhalation combined with tulobuterol tape in treatment of recurrent wheezing in infants and young children. MethodsSixty-two infants and young children with recurrent wheezing were randomly divided into treatment group（n=31） and control group（n=31）.When wheezing was relieved,patients in treatment group were treated with budesonide suspension fluid inhalation combined with tulobuterol tape for 12 weeks,while those in control group were treated with budesonide suspension fluid inhalation only.Patients were followed up during the 2nd,4th,6th,8th,10th and 12th week,and the frequencies of cough and respiratory tract infection and the condition of combination use of drugs were analysed. ResultsThirty patients in treatment group and 29 patients in control group completed the treatment and follow up.The scoring of cough,frequency of wheezing,scoring of wheezing and scoring of combination use of drugs in treatment group were significantly lower than those in control group（P0.01）,and the frequency of respiratory tract infection in treatment group was significantly lower than that in control group（P0.05）. ConclusionBudesonide suspension fluid inhalation combined with tulobuterol tape is more effective and safe than budesonide suspension fluid inhalation only in treatment of recurrent wheezing in infants and young children.