苯丙醇胺肠吸收特性的研究

A study of feature of phenylpropanolamine absorption in intestine

目的:研究苯丙醇胺在肠道中的吸收特点。方法:采用在体大鼠肠段回流实验,对苯丙醇胺的吸收特性从其主要影响因素pH值、吸收部位、药物浓度3个方面进行研究。结果:回流液的pH值对吸收有显著影响,pH值在7.4～6.5之间呈特定吸收;在十二指肠及空肠上、中段的吸收明显大于下段和回肠;药物浓度在50～400μg·ml-1范围内无高浓度饱和现象,吸收系数基本保持不变。

OBJECTIVE:To study the feature of phenylpropanolamine absorption in intestine.METHODS:With regurgitation test in intestine segment of rat in vivo,studing the main influence factors of pH value,sbsorption location and drug concentration of phenylpropanolamine absorption.Drug content was determined with acid dye chromatometry,wave length 420nm,linear rang 0～100μg·ml -1 and r = 0.999 8 .RESULTS:The absorption was obviously influenced by pH value of regurgitation fluid.The characteristic absorption occurred between pH 7.4 ～ 6.5 .The absorption content was obviously geater in the upper and medium parts than in the lower parts of deodenum and jejunum as well as in ilenum.No saturation of high concentration was observed when drug concentration is in rang of 50～400 μg·ml -1 .Absorption quotient was kept unvaried basically.CONCLUSIONS:Phenylpropanolamine was pasitively absorbed by transferring in intestine.