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系统性红斑狼疮患者4种尿微量蛋白检测结果分析 被引量:7

The Result Analysis of Four Kinds of Urine Microprotein in Systemic Lupus Erythematosus
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摘要 目的探讨尿微量白蛋白、转铁蛋白、α1-微球蛋白、β2-微球蛋白在SLE患者早期肾损害监测中的意义。方法 SLE患者108例,依据是否有肾脏的临床表现分为两组:有肾脏表现组和无肾脏表现组。65名健康献血者为正常对照组。收集受检者晨起第2次尿液,采用免疫散射比浊法定量检测尿微量白蛋白、转铁蛋白、α1-微球蛋白、β2-微球蛋白。血清尿素氮、肌酐的检测采用全自动生化仪(东芝120)检测。结果有肾脏表现组4种微量蛋白均高于无肾脏表现组和对照组(P<0.05),无肾脏表现组4种微量蛋白均高于对照组(P<0.05)。4项指标单独检测的阳性率在无肾脏表现组、有肾脏表现组组内比较,差异均无统计学意义(P>0.05)。而分析4种微量蛋白联合检测阳性率的结果,发现在无肾脏表现组1项指标阳性率与2项指标阳性率比较,3项指标阳性率与4项指标阳性率比较,差异无统计学意义(P1,2;P3,4>0.05)。而1项指标阳性率与3项指标阳性率比较,与4项指标阳性率比较;2项指标阳性率与3项指标阳性率比较,与4项指标阳性率比较,差异有统计学意义(P1,3;P1,4;P2,3;P2,4<0.05)。在有肾脏表现组结果与无肾脏表现组结果相同。有肾脏表现患者的尿中微量白蛋白、转铁蛋白、α1-微球蛋白、β2-微球蛋白与血清尿素氮之间无统计学相关性;尿中转铁蛋白、α1-微球蛋白、β2-微球蛋白与血清肌酐之间无统计学相关性,P>0.05;而尿微量白蛋白与血清肌酐之间呈正相关,r=0.737,P<0.05。结论 4种指标联合检测可以大大提高阳性检出率,提示系统性红斑狼疮患者早期动态观察监测尿微量蛋白的类型与含量,对患者肾早期损伤的诊断具有非常重要的临床价值。 Objective To explore the significance of the urine microalbumin,transferrin,alpha 1-microglobulin,beta 2-microglobulin in SLE patients with early renal damage.Methods One hundred and eight patients with SLE,based on whether had the clinical manifestations of the kidney,were divided into two groups,obvious lupus nephritis group and silent lupus nephritis group,sixty-five healthy donors for normal control group.Immunol scatter turbidity test was used to assay microalbumin,transferrin,alpha 1-microglobulin,beta 2-microglobulin.The automatic biochemistry analyzer(Toshiba 120) was used to assay Serum BUN and Cr.Results The four kinds of microprotein in obvious lupus nephritis group were higher than that in silent lupus nephritis group and the control(P0.05).The four kinds of microprotein in silent lupus nephritis group were higher than those in the control group(P0.05).There were no statistical significance of four performance alone in obvious lupus nephritis group and in silent lupus nephritis group(P0.05).The four kinds of microprotein were jointly tested in Silent Lupus nephritis group.It's found that there was no statistical significance in positive frequency comparing to one index and two indexes,three indexes and four indexes(P 1,2;P3,40.05).However there was statistical difference in comparing one index and three indexes,one index and four indexes,two indexes and three indexes,two indexes and four indexes(P 1,3;P 1,2;P 2,3;P 2,40.05).The result in obvious lupus nephritis group was the same.There was no relationship between urine microalbumin,transferrin,alpha 1-micro globulin,beta 2-micro globulin and serum BUN.There was no statistics correlation between urine transferrin,alpha 1-micro globulin,beta 2-micro globulin and serum creatinine(P0.05).While there was positive relationship between urinary microalbumin and serum creatinine(r=0.737,P0.05).Conclusion The four index united detection can greatly improve the positive rate,indicating the significiance of dynamic monitoring the types and content of urine microprotein to early diagnosis of renal injury in SLE.
出处 《中国皮肤性病学杂志》 CAS 北大核心 2012年第2期170-172,共3页 The Chinese Journal of Dermatovenereology
关键词 系统性红斑狼疮 微量白蛋白 转铁蛋白 Α1-微球蛋白 Β2-微球蛋白 SLE Microalbumin Transferrin Alpha1-microglobulin Beta2-microglobulin
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参考文献6

  • 1Behara VY,Whittier WL,Korbet SM,et al.Pathogenetic features of severe segmental lupus nephritis[J].Nephrol Dial Transplant,2010,25(1):153-159.
  • 2李圣楠,黄慈波.系统性红斑狼疮的诊断治疗进展[J].临床药物治疗杂志,2010,8(1):6-10. 被引量:85
  • 3Schwartz M,Korbet S,Katz R,et al.Evidence of concurrent immunopathological mechanisms determining the pathology of severe lupusnephritis[J].Lupus,2009,18(2):149-158.
  • 4Branten AJ,dubuf-Vereijken PW,Klasen IS,et al.Urinary excretion of β2-M and IgG predict prognosis in idiopathic membranous nephropathy:a validation study[J].J Am Soc Nephro1,2005,16(1):169-174.
  • 5Madalewa L,Facio ML,Angerosa M,et al.Urinary excretion of lowmolecular weight proteins in patients with pure monoclonal light chain proteinuries[J].J Nephrol,2007,20(6):683-688.
  • 6Schwartz MM,Korbet SM,Lewis EJ.The prognosis and pathogenesis of severe lupus glomerulonephritis[J].Nephrol Dial Transplant,2008,23(4):1298-1306.

二级参考文献8

  • 1Bertsias G, Ioannidis JPA, Boletis J,et al. EULAR recommendations for the management of systemic lupus erythematosus. Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics [J]. Ann Rheum Dis,2008, 67 : 195- 205.
  • 2Ad Hoe Working Group on Steroid-Sparing Criteria in Lupus. Criteria for steroid-sparing ability of interventions in systemic lupus erythematosus: report of a consensus meeting [J]. Arthritis Rheum 2004 ;50:3427- 3431.
  • 3Lu F, Tu Y, Peng X, et al. A prospective muhicentre study of mycophenolate mofetil combined with prednisolone as induction therapy in 213 patients with active lupus nephritis[J]. Lupus,2008,17: 622- 629.
  • 4Zhang FS, N ie YK,Jin XM,et al. The efficacy and safety of leflunomide therapy in lupus nephritis by repeat kidney biopsy [J]. Rheumatol Int,2009,29(11):1331- 1335.
  • 5Austin H. Lupus membranous nephropathy:controlled trial of prednisone,pulse cyclophosphamide and cyclosporine A [J].J Am Soe Nephrol,2004,15:54A.
  • 6Jayne D, Passweg J, Marmont A, et al. Autologous stem cell transplantation for systemic lupus erythematosis [ J ]. Lupus, 2004,13 : 168-176.
  • 7Sun L, Akiyama K, Zhang H, et al. Mesenchymal stem cell transplantation reverses multlorgan dysfunction in systemic lupus erythematosus mice and humans [ J ]. Stem Cells. 2009,27 : 1421 - 1432.
  • 8赖蓓,张春媚,夏群,陈颖娟,马喻庆,黄慈波.羟氯喹在风湿病治疗中眼部不良反应的初步调查[J].药物不良反应杂志,2008,10(3):177-179. 被引量:8

共引文献84

同被引文献65

  • 1余彩明,李美华,高鲁平.血及尿中β_2微球蛋白检测在各期SLE中的价值[J].实用医技杂志,2004,11(06A):878-879. 被引量:2
  • 2李炜煊,周丽清.血清CystatinC及尿GAL、NAG检测在肾脏病中应用[J].国际医药卫生导报,2004,10(16):30-31. 被引量:3
  • 3王禹,刘林林,李艳秋,王力宁.系统性红斑狼疮患者尿微量蛋白测定的临床意义及其与肾脏病理改变的关系[J].中华风湿病学杂志,2006,10(4):227-229. 被引量:11
  • 4Yee CS, Isenberg DA, Prabu A, et al. BILAG-2004 index captures sys- temic lupus erythematosus disease activity better than SLEDAI-2000 [ J ]. Ann Rheum Dis, 2008,67 ( 6 ) : 873-876.
  • 5Mevorach D. Clearance of dying cells and systemic lupus erythemato- sus :the role of C1 q and the complement system[ J ]. Apoptosis,2010, 15(9) :1114-1123.
  • 6Hochberb MC.Updating the Ameriran College ofRheumatology revised criteria for the classification ofsystemic lupus erythematosus[J].Arthritis Rheum,1997,40(9):1725.
  • 7Marks SD1 Shah V,Pilkington C,et al.Renaltubular dysfunction in children with systemic lupuserythematosus[J],Pediatr Nephrol,2005,20(2):141-148.
  • 8Corti M, Palmero D, Eiguchi K. Respiratory infections in immunocompromised patients[J]. Curr Opin Pul Med, 2009,15(3): 209-217.
  • 9Resende AL, Titan SM, Barros RT, et al. Worse renal out- come of lupus nephritis in male patients: a case-control study[J]. Lupus,2011,20(6) :561-567.
  • 10Chiu PW, Ng EK. Predicting poor outcome from acute upper gastrointestinal hemorrhage[J]. Gastroenterol Clin N Am,2009,38(2) :215-230.

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