MSCT征象与肿瘤因子的关系及联合检测对肺癌诊断价值的研究

Study on the Correlation of MSCT Features and Tumor Markers and the Diagnostic Value of the Combined Detection for Pulmonary Carcinoma

目的研究多层螺旋CT(multi-slice spiral computed tomography,MSCT)形态学特征与血清肿瘤标志物非小细胞肺癌抗原(lung tumor antigen,LTA)、癌胚抗原(carcino-embryonic antigen,CEA)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)的关系和两种检测方法联合应用在肺癌诊断中的价值。资料与方法 64例经病理证实的肺部恶性病变和64例良性病变患者行MSCT扫描和血清肿瘤标志物LTA、CEA、NSE检测,MSCT扫描图像通过多种后处理技术重组全面观察恶性病变影像学特征,MSCT特征与血清肿瘤标志物进行对照分析。并对良恶性病变血清肿瘤标志物进行比较。结果患者血清肿瘤标志物LTA、CEA、NSE与肿瘤大小、毛刺征、空泡征、实性结节、胸膜凹陷征、支气管截断征、胸腔积液无统计学意义,NSE、CEA与淋巴结转移无统计学意义(P>0.05),LTA与淋巴结转移有统计学差异(P<0.05)。结论 MSCT形态特征和血清肿瘤标志物两种方法联合对肺部恶性病变鉴别具有重要意义。

Objective To study the correlation between multi slice spiral CT features and serum tumor markers which include Lung tumor antigen（LTA）,Carcino embryonic antigen（CEA）,Neuron specific enolase（NSE）,and assess the value of both methods in the differential diagnosis of lung cancer.Materials and Methods 64 cases of pathologically confirmed pulmonary malignant lesions and 64 benign lesions received MSCT scanning and serum tumor markers LTA,CEA,NSE detection,MSCT images with post processing reconstruction were used to analyze imaging features of malignant nodules,the relation between MSCT features and serum tumor markers of benign and malignant lesions were compared.Results The relationship between Serum tumor markers LTA,CEA,NSE and the clinical stage,tumor size,spiculation sign,vacuole sign,solid nodules,pleural indentation,signs of bronchial,vascular gathered sign,pleural effusion was no significant difference,there was no statistically significant difference between NSE,CEA and lymph node metastasis（P 0.05）,there was significant difference between LTA and lymph node metastasis（P 0.05）.Conclusion Combine MSCT morphological characteristics with serum tumor markers are helpful in the differential diagnosis of lung cancer.