毒蕈碱受体M3的表达与呼吸道疾病被引量：3

Expression of Muscarinic Receptor M3 and Airway Diseases

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摘要 M3受体广泛分布于呼吸道平滑肌中,通过与乙酰胆碱结合而引起呼吸道收缩,腺体分泌和呼吸道重构。近年研究表明,哮喘和慢性阻塞性肺疾病炎性反应中产生的各种炎性因子,如白细胞介素1β、白细胞介素13、肿瘤坏死因子α和干扰素γ等能影响M3受体在呼吸道内的表达,使M3受体表达上调。因此,使用长效选择性胆碱能受体拮抗剂能延缓肺功能下降,在慢性阻塞性肺疾病的治疗中有重要作用。 M3 mAChRs expressed in airway smooth muscle（ASM）cells promote increased ASM tension,therefore airway narrowing,mucous secretion,and airway remodeling in response to acetylcholine release from postganglionic parasympathetic nerves innervating the airway.Recent novel studies suggest that airway inflammation associated with asthma and COPD increase vagal tone;this results from exaggerated acetylcholine release and enhanced expression of downstream signaling components such as IL-1β,IL-13,tumor necrosis factor-α and IFN-γ in airway smooth muscle.Therefore long-acting anticholinergic drug can effectively inhibit accelerated decline of lung function in COPD patients,making it play an important role in COPD treatment.

作者王羽戴路明

机构地区昆明医学院第一附属医院呼吸二科

出处《医学综述》 2012年第1期31-33,共3页 Medical Recapitulate

关键词毒蕈碱受体呼吸道疾病慢性阻塞性肺疾病 Muscarinic receptor Airway disease COPD

分类号 R962 [医药卫生—药理学]

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