缺血后处理在先天性心脏病手术中对未成熟心肌的保护作用

Effect of Ischemic Postconditioning for Immature Myocardium Protection in Congenital Heart Diseases Surgery

近年来,缺血后处理(I-postc)作为一种传统心肌保护方式以外的有效途径,已被越来越多的应用于临床实践中。其用于成熟心肌的保护效果得到较一致的肯定。未成熟心肌结构、代谢及功能较成熟心肌差别较大,针对未成熟心肌I,-postc心肌保护效果的临床研究以及与传统心肌保护方法(包括缺血预处理)比较和协同研究报道较少。现就I-postc的心肌保护机制、研究现状及其在未成熟心肌保护中的应用进行综述。

In recent years,ischemic postconditioning（IPC）has been more and more applied in clinical practice as an effective way besides the traditional myocardium′s protection,which has obtained consistent affirmation in mature cardiac muscles′ protection.The structure,metabolism and function of immature myocardium are of great difference with mature myocardium.There is only few reports of clinical study of immature myocardium,IPC protection effect and the comparative and synergetic study with the traditional cardioprotective methods（including ischemia preconditioning）.Here is to make a review on the protection mechanism,present research situation and application of IPC in immature myocardium protection.