急性缺血缺氧性脑病神经保护的治疗进展

Progress of Acute Hypoxic-ischemic Encephalopathy Neuroprotective Treatment

急性缺血缺氧性脑病是多种因素或机制共同或先后作用的结果,近年来急性缺血缺氧性脑病的神经保护颇受国内外学者的重视。但目前各种神经保护治疗的作用机制及疗效均尚未明确,现就亚低温、高压氧、正压通气、血液净化等非药物治疗,糖皮质激素、纳洛酮、神经节苷脂、依达拉奉、促红细胞生成素等药物治疗及干细胞移植等治疗方法的进展情况予以综述。

Acute hypoxic-ischemic encephalopathy is a result caused by varieties of factors or mechanisms,jointly or successively.In recent years,acute hypoxic-ischemic encephalopathy neuroprotective has attracted wide attentions both at home and abroad.However,the function mechanisms and therapeutics of various neuroprotective treatments are not clear yet.Here is to make a review on the non-drug treatments such as hypothermia,hyperbaric oxygen,positive pressure ventilation,blood purification and odrug treatments such as corticosteroids,naloxone,gangliosides,edaravone,erythropoietin,UTI etc.and stem cell transplantation.