激素性骨坏死动物模型研究进展

Advance of Experimental Animal Models of Steroid-induced Osteonecrosis

骨坏死或缺血性坏死是一种常见的骨代谢疾病,可以发生在全身多个部位,临床上以股骨头坏死(ONFH)最为常见。随着激素性药物在临床上的广泛应用,糖皮质激素已成为造成非创伤性ON-FH的主要原因之一。虽然可以通过许多生物学、生物物理学和手术方式进行ONFH的保头治疗,但结果都不能令人满意。在各种预防和治疗骨坏死的方法应用于临床之前,首先必须通过建立相关的动物模型更科学、准确地检验这些方法的有效性。现就目前国内外激素性骨坏死动物模型建模方法研究进展进行综述。

Osteonecrosis（ON）or avascular necrosis is a common bone metabolic disorder,mostly affecting femoral head,called osteonecrosis femoral head（ONFH）.One of the most common risk factors for ONFH is use of corticosteroids.Although many biological,biophysical,and surgical methods have been tested to preserve the femoral head with ON,none has been proven fully satisfactory.A number of preclinical animal steroid-induced ON models have been established for testing potential efficacy of various modalities developed for prevention and treatment of steroid-induced ON before introduction into clinics for potential applications.Here is to make a review on a number of different methods for creating experimental animal models of steroid-induced ON.