参佛胃康对大鼠慢性萎缩性胃炎及胃癌前病变逆转作用的研究

Reverse effects of Chinese drug Shenfouweikang herbs on chronic atrophic gastritis in rats

目的:观察参佛胃康对大鼠慢性萎缩性胃炎及胃癌前病变的逆转作用,探讨其作用机制。方法:采用主动免疫、去氧胆酸钠、热水灌胃综合法连续造模90d,复制慢性萎缩性胃炎(CAG)大鼠模型,空白组自由饮水,模型组用等体积的蒸馏水灌胃,丽珠得乐组用丽珠得乐溶液0.018mg/kg灌胃,参佛胃康大剂量组、参佛胃康小剂量组分别用参佛胃康溶液2.44mg/kg和0.61mg/kg灌胃。肉眼观察胃黏膜的变化,光镜下观察胃黏膜的病理学改变,同时测定大鼠胃液pH值及胃蛋白酶活性的变化。结果:参佛胃康能保护大鼠慢性胃黏膜损伤,增加胃液酸度提高胃蛋白酶活性,且参佛胃康大剂量组效果显著。结论:参佛胃康对慢性胃萎缩性胃炎黏膜的各种病理变化具有明显的逆转作用。

Objective：To determine the reverse effect of Shenfouweikang herbs on experimental chronic atrophic gastritis（CAG）in rats.Methods： CAG model in rats was made using complex methods of active immunization combined with oral administration of sodium deoxycholate and hot water for 90 d.Five animal groups were divided.Empty control group was fed with water,while experimental animal groups were fed with distilled water,0.018mg Lizhudele herds solution per kg weight of rat,2.44mg high dose and 0.61mg low dose of Shenfouweikang herbs solution per kg weight of rat for 90 days.Then the acidity of gastric juice was measured using acid-base balance.Pathology of rat gastric mucous morphology was examined by general observation and microscopy.At the same time,rat gastric pH value and pepsin content were detected by spectrophotometer.Results： After treated with Shenfouweikang herbs,rat gastric pH value and pepsin content increased and gastric mucous morphology was recovered,which presented a significant effect with high dose of Shenfouweikang herbs.Conclusion： Shenfouweikang herbs demonstrated a distinct preventive and protective effect on chronic atrophic gastritis（CAG）in rats.