期刊文献+

基于树突状细胞的肿瘤免疫治疗研究进展 被引量:10

Progress in dendritic cells cell-based immunotherapy of tumor
下载PDF
导出
摘要 树突状细胞(dendritic cells,DC)是目前已知最强的抗原递呈细胞。近年来,人们对DC在肿瘤免疫治疗中的作用等研究取得了快速发展,大量研究资料表明DC在肿瘤特异性免疫反应过程中起重要作用。本文主要对DC的生物学特性、抗肿瘤机制及临床应用作一介绍。 Dendritic cell is the most powerful antigen-presenting cell in human body.Great progress had been achieved in the research on the mechanism and clinical application of dendritic cell,and numerous studies indicated that dendritic cell play an important role in the tumor-specific immunity.This review was to summarize the immunity,function and clinical application of dendritic cell.
出处 《现代肿瘤医学》 CAS 2012年第2期409-411,共3页 Journal of Modern Oncology
基金 湖南省科技厅课题资助(编号:S2010S20332336)
关键词 树突状细胞 肿瘤 免疫治疗 Exosomes小体 dendritic cell tumor immune therapy exosomes
  • 相关文献

参考文献18

  • 1Apetoh L,Locher C,Ghiringhelli F,et al.Harnessing dendritic cells in cancer[J].Semin Immunol,2011,23(1):42-49.
  • 2Fukui H,Mitsui S,Harima N,et al.Novel functions of herbal medicines in dendritic cells:role of amomi semen in tumor immunity[J].Microbiol Immunol,2007,51(11):1121-1133.
  • 3McKenna K,Beignon A,Bhardwaj N.Plasmacytoid dendritic cells:linking innate and adaptive immunity[J].J Virol,2005,79(1):17-27.
  • 4Baumgart DC,Thomas S,Przesdzing I,et al.Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease[J].Clin Exp Immunol,2009,157(3):423-436.
  • 5Lim TS,Mortellaro A,Lim CT,et al.Mechanical interactions between dendritic cells and T cells correlate with T cell responsiveness[J].J Immunol,2011,187(1):258-265.
  • 6Ma J,Usui Y,Takeuchi M,et al.Human uveal melanoma cells inhibit the immunostimulatory function of dendritic cells[J].Exp Eye Res.2010,91(4):491-499.
  • 7Lou Y,Liu C,Kim GJ,et al.Plasmacytoid dendritic cells synergize with myeloid dendritic cells in the induction of antigenspecific antitumor immune responses[J].Immunol,2007,178(3):1534-1539.
  • 8Baumgart DC,Carding SR.Inflammatory bowel disease:cause and immunobiology[J].Lancet,2007,369(9573):1627-1640.
  • 9茹颖,宋红梅,李航,崔巍.TNF-α促进树突状细胞分化成熟的实验研究[J].中国实验血液学杂志,2010,18(5):1265-1268. 被引量:7
  • 10Ohgimoto K,Ohgimoto S,Ihara T,et al.Difference in production of infectious wild-type measles and vaccine viruses in monocyte-derived dendritic cells[J].Virus Res,2007,123(1):1-8.

二级参考文献24

  • 1吴雨岗,汪良,张雁云.人外周血树突状细胞的体外扩增、鉴定及内吞能力的测定[J].中国血液流变学杂志,2004,14(4):444-447. 被引量:6
  • 2王媛,杨爱珍,陈惠英,乐美兆,秦叔逵.人外周血树突状细胞的体外诱导和鉴定[J].临床肿瘤学杂志,2004,9(6):597-600. 被引量:5
  • 3张工梁 郑素琴 等.分离T、B淋巴细胞的简易方法[J].上海免疫学杂志,1986,6(3):184-184.
  • 4Thomas R, Davis LS, Lipsky PE. Comparative accessory cell function of human peripheral blood dendritic ceils and monocytes. J Immunol, 1993 ; 151 (12) :6840 -6852.
  • 5Pulendran B, Dillon S, Joseph C, et al. Dendritic cells generated in the presence of GM-CSF plus IL-15 prime potent CD8^+ Tcl responses in vivo. Eur J Immunol,2004 ;34 ( 1 ) :66 - 73.
  • 6Coutant F, Perrin-Cocon L, Agaugue S, et al. Mature dendritic cell generation promoted hy lysophosphatidylcholine. J Immunol, 2002; 169(4) :1688 - 1695.
  • 7Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by culture human dendritic ceils is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin-4 and downregulated by tumor necrosis factor-α. J Exp Med, 1994 ; 179(4) : 1109 - 1118.
  • 8Banchereau J, Briere F, Caux C, et al. Immunohiology of dendritic cells. Annu Rev Immunol,2000 ; 18 : 767 - 811.
  • 9Chapoval AI, Tamada K, Chen L. In vitro growth inhihition of a broad spectrum of tumor cell lines by activated human dendritic cells. Blood,2000 ;95 (7) :2346 - 2351.
  • 10Dadaglio G, Sun CM, Lo-Man R, et al. Efficient in vivo priming of specific cytotoxic T cell responses by neonatal dendritic cells. J Immunol, 2002 ; 168 ( 5 ) : 2219 - 2224.

共引文献11

同被引文献161

引证文献10

二级引证文献43

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部