江苏省2005～2010年抗病毒治疗艾滋病患者流行病学特征比较分析

Epidemiological analysis on the characteristics of patients with highly active antiretroviral therapy during 2005 to 2010 in Jiangsu province

目的:了解2005～2010年江苏省艾滋病免费抗病毒治疗患者入组时的流行病学特征,比较分析其变化情况,为江苏省进一步实施艾滋病免费抗病毒治疗工作提供依据。方法:收集江苏省2005～2010年内所有接受抗病毒治疗艾滋患者入组治疗时的基本情况,建立Excel数据库并用SPSS17.0软件分析并比较其流行病学特征变化趋势。结果:江苏省2005～2010累计治疗1 276例艾滋病患者,新增治疗人数逐年上升,增幅逐年扩大。江苏籍占93.7%,男女性别比2.7∶1。平均年龄(39.2±11.0)岁,变化不大,但低年龄组有上升趋势。已婚或同居占65.1%。来源主要为医院被动发现,占40.9%,但有下降趋势。感染途径主要为异性性传播和同性性传播,两者合计占76.1%,同性性传播比例逐年上升,2010年达到32.8%。患者治疗时CD4+T细胞平均为134.9个/μl,开始治疗时间与确证时间的间隔天数中位数为147 d(P25=55,P75=489),有上升趋势。结论:江苏省艾滋病患者开始抗病毒治疗时机较晚,但逐渐有所改善。患者发现晚仍是主要原因,感染者早发现能力仍需加强。

Objective： To analyze and compare the epidemiological characteristics of the patients who received highly active antiretroviral therapy（HAART） during 2005 to 2010 in Jiangsu province.Methods： According to the base data of patients during 2005 to 2010,Excel database was established and statistical analysis was performed using SPSS 17.0 software.Results： There were 1 276 patients during 2005 to 2010 totally,the number of patients were increasing by the year.There was 93.7% of the patients from Jiangsu province;the ratio of male to female was 2.7∶1;the average age was 39.2 years old and the number of young patients aged 16 to 25 was increasing;65.1% of the patients have married;patients were mainly detected and diagnosed by hospitals;76.1% of the patients were infected with HIV through sexual transmission,while the proportion of men who have sex with men（MSM） is significantly higher in 2010 than before;the average CD4＋ T cell counts of cases were only 134.9 counts/μl;147 days as the median of the interval between the time of HIV confirmation and anti-retroviral therapy（ART） beginning,both of them are significantly different from those during 2005 to 2009.Conclusion： It＇s late for the AIDS to start HAART in Jiangsu province during 2005 to 2010,although it＇s earlier than before.In view of the AIDS patients were diagnosed at late stage,earlier detection and diagnosis of HIV positive cases still should be strengthened.