对甲苯磺酸催化查尔酮的合成

Synthtsis of Chalcone Catalyzed by P-toluenesulfonic Acid

研究了查耳酮的制备方法和缩合反应的影响因素选择最佳的反应条件,实验的结果表明,合成查尔酮的缩合反应的较佳条件是:n(苯乙酮)/n(间硝基苯甲醛)=1∶1,反应温度是70℃,反应的时间3 h,对甲苯磺酸为3 g,乙酸用量为20 mL,在此条件下查尔酮的收率达71.6%。

Synthesis methods of chalcone were studied,affecting factors of the condensation reaction were discussed so as to select the best reaction conditions.The experimental results show that the better reaction conditions of the synthesis are as follows： n（m-nitrobenzaldehyde） / n（preparation） = 1∶1,the reaction temperature is 70 ℃,the reaction time is 3 h,p-toluene sulfonic acid dosage and acetic acid dosage are 3 g and 20 mL,respectively.Under above conditions,the chalcone yield can reach 71.6%.