132例复发性外阴阴道假丝酵母菌病治疗观察

An observation on treatment for 132 patients with recurrent vulvovaginal candidiasis

目的探讨彻底治愈顽固性外阴阴道假丝酵母菌病的有效治疗方法。方法将本组132例病人随机分成观察组与对照组各66例，观察组在进行阴道假丝酵母菌检测的基础上另行衣原体及支原体检测。全部病人均给予氟康唑及达克宁栓，在此基础上，观察组66例病人需再给予抗支原体以及衣原体治疗措施。结果观察组66例病人均检出阴道假丝酵母菌，同时检出37例支原体及5例衣原体，衣原体＋支原体2例。对照组66例同样全部检出阴道假丝酵母菌，但未检测衣原体与支原体。观察组62例治愈，占93．94％；3例好转，占4．55％；1例无效，占1．51％。对照组32例治愈，占48．48％；22例好转，占33．33％；12例无效，占18．18％。观察组的疗效明显优于对照组，差异有显著性（Hc=18．90，P〈0．05）。结论在复发性阴道炎的治疗过程中，必须在综合治疗的基础上，做好病原体的检测工作，针对发病原因实施治疗，才能彻底治愈复发性阴道炎。

Objective To explore effective therapies to eradicate vulvovaginal candidiasis. Methods 132 patients were randomly divided into study group and control group, 66 for each group. The study group received detection of chlamydia and mycoplasma in addition to candida detection. All the patients were administered fluconazole and Gyno-Daktarin pessariea and the patients in the study group received additional therapies for infection with mycoplasma and chlamydia. Results In the study group, candida was detectable in all the patients; mycoplasma alone or chlamydia alone was found in 37 and 5, respectively; and coinfection with mycoplasma and chlamydia was found in 2. Candida was also detectable in all the patients in the control group, but no mycoplasma and chlamydia were found. 62 （ 93.94% ） patients were cured in the study group, 3 （ 4.55% ） had symptom improvement, and one （ 1.51% ） had no respons; while 32 （ 48.48% ） patients were cured in the control group, 22 （ 35.33% ） had symptom improvement, and 12 （ 18.18% ） had no response. The study group was markedly superior to the control group in the efficacy （ He = 18.90, P 〈 0.05 ）. Conclusions To completely cure recurrent vaginitis, it was important to detect the possible pathogens and to manage this disorder by targeting the pathogen.