奥美拉唑预防有机磷农药中毒并发上消化道出血的疗效观察

The efficacy of omeprazole in the prevention of upper gastrointestinal hemorrhage sec- ondary to organophosphorus intoxication

目的探讨奥美拉唑预防口服急性有机磷农药中毒并发上消化道出血的疗效。方法262例急性有机磷农药中毒患者随机分为2组，对照组按有机磷农药中毒常规治疗，治疗组按有机磷农药中毒常规治疗同时使用奥美拉唑预防上消化道出血。比较对照组和治疗组出现上消化道出血的发病率、输血情况和死亡情况。结果对照组上消化道出血18例，发病率为14．51％（18／124），输血14例，平均输血量为（343±199）ml，死亡率为4．03％（5／124）o治疗组上消化道出血7例，发病率为5．07％（7／138），输血3例，输血量均200ml，死亡率为1．44％（2／138）。结论奥美拉唑可预防口服急性有机磷农药中毒患者合并上消化道出血，降低发病率，减少临床输血量。

Objective To investigate the efficacy of omeprazole in the prevention of upper gastrointestinal hemorrhage secondary to acute oral organophosphorus intoxication. Methods 262 patients with organophosphorus intoxication were randomly assigned to two groups. The control received conventional therapy, while the study group received omeprazole in addition to conventional therapy. The incidence rate of upper gastrointestinal hemorrhage, rate of blood transfusion, and mortality rate were compared between the two groups. Reanlts In the control group, 18 of 124 （ 14.51% ） patients developed upper gastrointestinal bleeding; 14 needed blood transfusion, with an average amount of （ 343 ＋ 199 ） ml; and 5 （ 4.03% ） were dead. In the study group, 7 of 138 （ 5.07% ） patients occurred upper gastrointestinal bleeding ; 3 received blood transfusion, with an average amount of 200ml ; and 2 （ 1.44% ） were dead. Conclusions Omeprazole can prevent upper gastrointestinal hemorrhage secondary to acute oral organophosphorus intoxication and can lower the incidence of bleeding and the amount of blood transfusion.