布托啡诺联合咪哒唑仑对区域麻醉的镇静效果分析

The sedative effect of butorphanol combined with midazolam for regional anesthesia

目的探讨布托啡诺联合咪哒唑仑对区域麻醉的镇静效果。方法102例区域麻醉手术患者作为研究对象，随机分为实验组和对照组，实验组给予咪哒唑仑联合布托啡诺镇静，对照组给予咪哒唑仑联合芬太尼镇静。结果（1）两组感觉，运动阻滞起效时间和手术时间均差异无显著性（均P〉0．05）。（2）实验组MAP，HR和SPO，在围手术期基本稳定（P〉0．05），对照组术中MAP和HR和实验组相比有显著性变化（MAP：实验组（87．0±13．3）mmHg，对照组（98．2±18．2）mmHg；HR：实验组（89．5±13．4）次／mine，对照组（81．2±16．5）次／mine）（MAP：t=4．537，P〈0．05；HR：t=4．537，P〈0．05）。结论咪哒唑仑联合布托啡诺用于区域麻醉，有效性和安全性高，值得临床考虑。

Objective To explore the sedative effect of butorphanol combined with midazolam for regional anesthesia. Methods 102 patients schedualed for surgery under regional anesthesia were randomly divided into study group and control group. The study group were administered butorphanol combined with midazolam for sedation, and the control group received butorphanol plus fentanyl. Results Time to sensation and motor blockage and surgical duration did not differ significantly between the two groups （ P〉 0.05 for all comparisons ）. MAP, HR, and SpO2were stable in the study goup （ P〉 0.05 for all comparisons ） during the perioperative period, and MAP and HR in the control group significantly changed as compared with the study group [MAP： （ 87.0± 13.3 ） mmHg in the study group and （ 98.2 ± 18.2 ） mmHg in the control group; HR： （ 89.5 ± 13.4 ） cpm in the study group and （ 81.2 ± 16.5 ） cpm in the control group; MAP： t = 4.537, P 〈 0.05; HR： t = 4.537, P 〈 0.05]. Conclusions Butorphanol combined with midazolam for regional anesthesia is effective and safe, so it is worth clinically choosing.